In-Vitro Antioxidant, Anti-Arthritis, Anti-inflammatory, Thrombolysis, Anti-bacterial, and in-Vivo Neuropharmacological Activities of Bioactive Metabolites of Solanum americanum Mill.

Aims: The purpose of this research was to examine the effects methanol-prepared leaf extracts from Solanum americanum Mill. plant on a variety in vitro activities, including antioxidant, anti-Arthritis, anti-inflammatory, thrombolysis, anti-bacterial, and in-vivo neuropharmacological activities.
 Study Design: Methanolic extract (MESAL) primarily evaluated via phytochemical screening. potential for anti-arthritis, anti-bacterial activity were determined study due pharmacological interest plant's chemical constituent. Whether there is statistical significance changes seen its vivo characteristics when tested experimental animals.
 Place Duration Study: This carried out between November 2022 January 2023 at Laboratory Phytochemistry Pharmacology Department Pharmacy Microbiology, Stamford University Bangladesh Council Scientific Industrial Research, Dhaka.
 Methodology: subjected screening utilizing test reagents thrombolytic, activities MESAL investigated. Antioxidant, anti-arthritic, antibacterial different doses DPPH Free Radical Scavenging Assay, Protein Denaturation Assays, Clot Lysis, Disk Diffusion Method. Swiss albino mice using open-field hole-cross methods measure their locomotion as part study.
 Results: findings demonstrated that plants' compositions varied. Most antioxidant found MESA, with an IC50 11.73 µg/mL compared Ascorbic acid's 28.86 µg/mL. When standard, percent inhibition value MESAL's anti-arthritis significantly higher. With maximum protein denaturation 94.03% concentration 1000µg/mL, possesses potent anti-inflammatory activity. terms clot lysis very significant which 90.257%. While moderate, it still worth considering. However, proven be less effective than Diazepam improving motor coordination Open Field Hole Cross Tests.
 Conclusion: Several pathological conditions, neurodegenerative diseases, may benefit future use plant-derived agents neuropharmacological, anti-arthritic activity, can replace NSAIDs.